AICAR (Acadesine) is a compound which has shown extremely impressive fat-loss and endurance-enhancing effects in laboratory animals. The peptide AICAR is a protein kinase agonist, meaning that it increases the usage of nutrient stores in order for the production of energy.

Used on the mice, AICAR induced metabolic genes and significantly improved running endurance by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch fibers.

AICAR stacked with GW-501516 activated 40% of the mice genes that were turned on when mice were administered GW and made to exercise. This finding shows that these peptides could provide the benefits of exercising without actually exercising.